2024 Klf6 inhibitor

Klf6 inhibitor

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WebAug 26, 2009 · Kruppel-like factor 6 (KLF6) is a tumour-suppressing protein. The aim of this study was to identify the role of KLF6 inhibition in estrogen receptor {alpha} (ERα)-elicited … WebJun 1, 2004 · Abstract. Kruppel-like factor 6 (KLF6) is a tumor suppressor gene inactivated in prostate and colon cancers, as well as in astrocytic gliomas. Here, we establish that …

The role of KLF transcription factor in the regulation of cancer ...

WebFeb 28, 2024 · Klf6 is a member of the Krüppel-like factor family, which is a group of zinc finger transcription factors involved in differentiation and development. In general, Klf6 gene plays an important... dr. wolfberg torrington ct

KIF6 - Wikipedia

WebBackground: Macrophage polarization regulates human inflammatory disorders.Results: KLF6 is a novel transcriptional regulator of macrophage polarization.Conclusion: KLF6 regulates macrophage inflammatory gene expression by modulating functions of NF-κB and PPARγ.Significance: Pharmacological agents that modulate KLF6 signaling may allow for … WebThis review focuses on four widely investigated KLF members, KLF2, KLF4, KLF6, and KLF7, describing their molecular characteristics, physiological functions, regulatory factors, roles in cancer, and treatment. ... Smad7 is an inhibitor of TGF-β, which is a tumor-suppressor in the early stages of various cancers, including GC and CRC [98 ... WebJul 1, 2005 · KLF6 is a member of the Kruppel-like family of zinc finger transcription factors which are DNA-binding proteins regulating growth-related signal transduction pathways, … comfy earbud covers

Cyclin-Dependent Kinase Inhibition by the KLF6 Tumor Suppressor …

The Klf6-related super enhancer deletion by CRISPR/Cas9

WebMay 23, 2016 · (M-O) Confocal imaging analysis of Klf6-silenced and NT control mouse OLP pretreated with 2 μM caspase inhibitor Q-VD-OPh or vehicle for 2 h, then differentiated with T3 for 48 h. Apoptosis is almost absent from cultures exposed to the inhibitor, and Olig2 + cell numbers in Klf6-silenced and control conditions are almost identical (M,N). WebBackground: Krüppel-like factor 6 (KLF6) is a transcription factor that participate in various pathophysiological processes, but its contribution in ischemia acute kidney injury (AKI) is … dr wolf beckWebNov 25, 2010 · Indeed, KLFs have been implicated in subtypes of leukemia, lymphoma, autoimmunity, and in acute and chronic inflammatory disease states, such as atherosclerosis, diabetes, and airway inflammation, raising the possibility that KLFs and their upstream signals are of therapeutic interest. comfy durable ren boots

"WebDec 22, 2006 · KLF6 is ubiquitinated in vivo. 293T cells were transiently transfected with pcDNA-KLF6 and hemagglutinin-tagged ubiquitin (pHA-Ub) and cultured for 2 h with the proteasome inhibitor ALLN or vehicle alone (DMSO). Equal amounts of protein were immunoprecipitated with anti-HA-antibody and Western blotted with anti KLF6 or anti-Flag … " - Klf6 inhibitor

Klf6 inhibitor

Role of Krüppel-like factors in leukocyte development, function, …

WebFeb 26, 2024 · However, KLF6 was identified as a tumor suppressor to inhibit glioblastoma by several research groups [34, 35]. Collectively, KLF6 may exert both anti-tumorigenic … WebDec 19, 2013 · KLF6 is ubiquitously expressed in human tissues and regulates many pathways such as differentiation, development, cellular proliferation, growth-related signal transduction, and apoptosis. ... KLF6 mRNA decreased within 45 min to 4 h in the presence of the transcription inhibitor actinomycin D and was reduced by 95% after 4 h of …

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Web(A) KLF5 and KLF6 mRNA expression in NB4 and NB4-R2 cells during ATRA-induced neutrophil differentiation. KLF5 and KLF6 mRNA levels were determined by RQ-PCR in control and ATRA-treated NB4 and... WebRecently, Klf6 super-enhancer which strongly regulates Klf6 gene expression has been identified, and the function of Klf6 super-enhancer which regulates cell growth was …

WebThe Klf6 gene is a tumor suppressor gene belonging to the family of the Klf gene and closely associated with tumor formation. Recently, super enhancers(SEs) have been shown to play a particularly... WebJul 30, 2024 · KLF6 directly activates E-cadherin transcription to inhibit tumor invasion and metastasis 13. Besides, KLF6 also suppresses cell migration and tumor metastasis in an E-cadherin-independent manner.

WebThe initial expansion of CD8 + effector T cells is followed by a contraction phase and concomitant development of CD8 + memory T cells [107].CD8 + memory T cells express IL-7 receptor (CD127) and IL-2 receptor β chain (CD122). The memory development is associated with the re-expression of CD62L and the up-regulation of CCR7, both of which … Webinhibitors of the KRAS substrate MEK, suggesting that KRAS signalling might mediate transcriptional regulation of polyamine syn-thesis. The authors identified KLF6 as a poten - tial transcription factor downstream of KRAS that facilitates this control, and KLF6 silencing diminished protein levels of OAT and other polyamine-synthesizing enzymes.

WebMar 18, 2024 · KLF6 is part of the Krüppel-like family and is a ubiquitously expressed nuclear transcriptional regulatory factor that is originally isolated and cloned from three independent tissues: placental cells ( Koritschoner et al., 1997 ), hepatic stellate cells ( Kim et al., 1998 ), and peripheral blood lymphocytes of B-cell chronic lymphocytic leukemia …

WebSep 14, 2006 · Furthermore, KLF6 inhibited cell proliferation partly through transactivating p21WAF1, which encodes a cyclin-dependent kinase inhibitor of the cell cycle in a p53-independent pathway (Narla et al., 2001). So KLF6 may play a role in cancer pathogenesis. However, the relation of KLF6 with HCCs is little known. comfy durable leather shoesWebSep 1, 2024 · Inhibition of KLF6 promoted the viability and reduced the inflammation and apoptosis of LPS-induced A549 cells, which was reversed by CYR61. Inhibition of KLF6 … comfy driving gameWeb目的:检测诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)在胃癌前病变及胃癌的表达,及其与幽门螺杆菌(Helicobacter pylori,Hp)感染的相关性,探讨Hp感染与胃癌发生的关系.方法:收集慢性浅表性胃炎(chronic superficial gastritis,CSG),慢性萎缩性胃炎伴肠上皮化生(Intestinal metapla dr wolf black rollWebc-Jun jest protein koji je kod ljudi kodiran genom JUN sa hromosoma 1. c-Jun, u kombinaciji sa c-Fos, formira AP-1 transkripcijski faktor za rani odgovor, Prvo je identificiran kao Fos-vezujući protein p39 i tek kasnije ponovo otkriven kao proizvod gena JUN. c-jun je bio prvootkriveni onkogeni transkripcijski faktor. The proto-oncogene c-Jun je ćelijski … comfy earphone tips for jaybird x2x2This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an importan… comfy earrings ear cuffsWebApr 2, 2013 · KLF6 is a member of the Krüppel-like Factors (KLF) gene family which are a group of transcription factors that contain three highly conserved Cys 2 -His 2 type zinc fingers located in the C-terminus [ 1, 2 ]. Subsequently, these proteins regulate a vast range of target genes by preferentially binding to cognate GC-boxes or CACCC elements. dr wolf birmingham orthoWebAug 22, 2024 · KLF6 expression increased axon extension, and combined VP16-STAT3/KLF6 expression significantly increased long distance axon growth above KLF6 alone. Arrowheads mark 1 mm intervals from the edge ... comfyeyeware